Expression and characterization of a dopamine D4R variant associated with delusional disorder

FEBS Letters

Henningsen, Robert²  Catalano, Marco³  Civelli, Olivier¹  Hartman, Deborah S²  Nobile, Maria³  Smeraldi, Enrico³  Zenner, Marie-Thérèse² 

[1] Department of Pharmacology, University of California, Irvine, CA, USA;Hoffmann-La Roche, Pharmaceutical Research, Preclinical Neuroscience, 4070 Basel, Switzerland;IRCCS H.S. Raffaele, DSNP, Milan, Italy

关键词: DFR1;    Polymorphism;    Schizophrenia;    Antipsychotic;    Antidepressant;    hD4R;    human dopamine D4 receptor;    DA;    dopamine;    DZP;    diazepam;    DMCM;    ethyl 4-ethyl-6;    7-dimethoxy-[9H]-pyrido[3;    4-b]indole-3-carboxylate;    CHO;    Chinese hamster ovary cells;   

DOI  :  10.1016/S0014-5793(97)01617-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Multiple genetic polymorphisms of the human dopamine D4 receptor (hD4R) have been identified including a 12 bp repeat in exon 1 associated with a psychotic condition called delusional disorder. Competition binding assays revealed minor pharmacological differences between the recombinant A1 (normal) and A2 (delusional) proteins with respect to quinpirole and the antipsychotic clozapine, however no functional differences were detected for receptor activation by dopamine, epinephrine, or norepinephrine. Our results suggest that this polymorphism may only confer susceptibility to delusional disorder in combination with other genetic or environmental factors.

【 授权许可】

Unknown