Resveratrol, a remarkable inhibitor of ribonucleotide reductase

FEBS Letters

Elleingand, Eric¹  Guittet, Olivier²  Lepoivre, Michel²  Fontecave, Marc¹  Gerez, Catherine¹ 

[1] Laboratoire de Chimie et Biochimie des Centres Redox Biologiques, DBMS-CEA/CNRS/Université Joseph Fourier, Bât. K, 17 Avenue des Martyrs, 38054 Grenoble Cedex 9, France;ERS CNRS 571, Université Paris Sud, Bât. 430, 91405 Orsay Cedex, France

关键词: Resveratrol;    Ribonucleotide reductase;    Tyrosyl radical;    Anticancer agent;   

DOI  :  10.1016/S0014-5793(97)01572-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Resveratrol, a natural phytoalexin found in grapes, is well known for its presumed role in the prevention of heart disease, associated with red wine consumption. We show here that it is a remarkable inhibitor of ribonucleotide reductase and DNA synthesis in mammalian cells, which might have further applications as an antiproliferative or a cancer chemopreventive agent in humans.

【 授权许可】

Unknown