Muscle/heart isoform of mitochondrial adenine nucleotide translocase (ANT1) is transiently expressed during perinatal development in rat liver

FEBS Letters

Giralt, Marta¹  Iglesias, Roser¹  Manchado, Carles¹  Viñas, Octavi¹  Mampel, Teresa¹  Grado, Angels¹ 

[1] Departament de Bioquı́mica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona. Av. Diagonal 645, 08028 Barcelona, Spain

关键词: Adenine nucleotide translocator;    Isoform;    Perinatal liver;    Respiration;   

DOI  :  10.1016/S0014-5793(97)01563-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A postnatal increase in the content of mitochondrial ANT in rat liver which is related to the maturation of mitochondrial function has previously been reported [Schönfeld et al., Biochim. Biophys Acta 1144 (1993) 353–358]. In order to define the contribution of the ANT isoforms to this postnatal increase we have studied the expression of ANT1 and ANT2 isoforms in the liver during this period. The results show that in contrast to adult liver, perinatal liver expressed the ANT1 isoform at the mRNA and protein level, and that during this period the expression of ANT1 increased to a similar extent as total ANT content. It is concluded that the postnatal increase in ANT is mainly due to the ANT1 isoform and therefore, a role for the ANT1 isoform in the postnatal maturation of mitochondrial respiration in rat liver is suggested.

【 授权许可】

Unknown