Alzheimer's α‐secretase may be a calcium‐dependent protease

FEBS Letters

Chen, Ming¹ 

[1] Department of Pharmacology and Therapeutics, University of South Florida College of Medicine, Tampa, FL 33612, USA

关键词: Alzheimer;    β-Amyloid;    Secretase;    Calcium;    Calpain;   

DOI  :  10.1016/S0014-5793(97)01214-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Proteolytic processing of β-amyloid precursor protein (APP) is believed to be fundamental to the understanding of Alzheimer's disease. The identities and the regulatory elements of the proteases involved in the process, known as α/β/γ secretases, are unclear. In this study, by examining reported data, we found some indications suggesting that the putative α-secretase may be a calcium-dependent protease, and that this enzyme may play a primary role in the regulation of APP processing. Based on this, we proposed a model for the membrane orientations of the secretases for further discussions.

【 授权许可】

Unknown