Alu sequences

FEBS Letters

Robinson, P.A.¹  Mighell, A.J.¹  Markham, A.F.¹ 

[1] Molecular Medicine Unit, The University of Leeds, Clinical Sciences Building, St. James's University Hospital, Leeds LS9 7TF, UK

关键词: Alu;    Repetitive DNA;    Retrotransposon;    Polymerase II;    Polymerase III;    Human genome;    FAM;    fossil Alu monomer;    flAlu RNA;    full-length Alu RNA;    FLAM;    free left arm monomer;    FRAM;    free right arm monomer;    RNA pol II;    RNA polymerase II;    RNA pol III;    RNA polymerase III;    scAlu RNA;    small cytoplasmic Alu RNA;    SRP;    signal recognition particle;   

DOI  :  10.1016/S0014-5793(97)01259-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Alu sequences are frequently encountered during study of human genomic nucleic acid and form a major component of repetitive DNA. This review describes the origin of Alu sequences and their subsequent amplification and evolution into distinct subfamilies. In recent years a number of different functional roles for Alu sequences have been described. The multiple influences of Alu sequences on RNA polymerase II-mediated gene expression and the presence of Alu sequences in RNA polymerase III-generated transcripts are discussed.

【 授权许可】

Unknown