Chicken thyroid hormone receptor α requires the N‐terminal amino acids for exclusive nuclear localization

FEBS Letters

Andersson, Monika L¹  Vennström, Björn¹ 

[1]Department of Cell and Molecular Biology (CMB), Medical Nobel Institute, Karolinska Institute, S-171 77 Stockholm, Sweden

关键词: Thyroid hormone receptor;    Subcellular localization;    P75gag-v-erbA;    Isoform;    N-terminus;    Chicken;   

DOI  :  10.1016/S0014-5793(97)01223-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The subcellular localization of natural and engineered forms of the chicken thyroid hormone receptor (cTRα) is dependent on amino acids encoded in the N-terminal region. The full length receptor protein, cTRα-p46, was found to localize exclusively to the nucleus, whereas the N-terminally shorter variant, cTRα-p40, localizes to both the nucleus and the cytoplasm. The exclusive nuclear localization of cTRα-p46 is dependent on the presence of the first 11 N-terminal amino acids, but independent of the phosphorylation of the serine at position 12. Our data identify a novel role for an N-terminal domain of the full length thyroid hormone receptor.

【 授权许可】

Unknown