The different inhibitory domains of the Oct‐2 transcription factor have distinct functional activities

FEBS Letters

Latchman, David S.¹  Dawson, Sally J.¹  Gay, Robert D.¹ 

[1] The Windeyer Institute for Medical Sciences, Department of Molecular Pathology, University College London Medical School, The Windeyer Building, 46 Cleveland Street, London W1P 6DB, UK

关键词: Oct-2 transcription factor;    Inhibitory domain;   

DOI  :  10.1016/S0014-5793(97)01184-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Oct-2 POU family transcription factor contains three distinct regions whose deletion reduces its ability to inhibit transcription via its octamer binding site. Here we show that only one of these inhibitory domains is capable of also inhibiting the activity of activating molecules bound at adjacent sites upstream of a TATA box-containing promoter whereas the other two regions are inactive in this assay. None of the three regions is able to achieve this effect when located upstream of the same promoter containing an initiator motif. The mechanisms of action of these domains and their role in the functioning of the Oct-2 factor are discussed.

【 授权许可】

Unknown