Distinct patterns of all‐trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small‐cell lung carcinoma cell lines

FEBS Letters

Flagiello, Domenico¹  Poupon, Marie-France¹  Gibaud, Anne¹  Malfoy, Bernard¹  Dutrillaux, Bernard¹ 

[1] Institut Curie - CNRS, UMR 147, 26, rue d'Ulm, 75248 Paris Cedex 05, France

关键词: Retinoic acid;    HOX gene;    Small-cell lung cancer;   

DOI  :  10.1016/S0014-5793(97)01118-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression patterns of the class I homeogenes HOXB and HOXC clusters in the presence of retinoic acid (RA) were studied in two human small-cell lung cancer (SCLC) cell lines and compared to that of NT2/D1 embryonal carcinoma cells. Contrasting with the sequential 3′-5′ induction of the HOX genes observed after RA treatment of embryonic NT2/D1 cells, in the SCLC cells the responding genes (induced or down-regulated) were interspersed with insensitive genes (expressed or unexpressed), while no genomic alteration affected the corresponding clusters. These findings imply that HOX gene regulatory mechanisms are altered in non-embryonic SCLC cells, perhaps reflecting their ability to respond to more diversified stimuli, in relation with their origin from adult tissues.

【 授权许可】

Unknown