Leptin interacts with glucagon‐like peptide‐1 neurons to reduce food intake and body weight in rodents

FEBS Letters

Rasheed, Shahnawaz²  Meeran, Karim²  Ghatei, Mohammed A.²  Rossi, Michela²  Howard, Jane K.²  Bloom, Stephen R.²  Hoggard, Nigel³  Moar, Kim M.¹  Goldstone, Anthony P.²  Turton, Mandy D.²  Mercer, Julian G.¹  Steere, Joanna²  Heath, Melanie M.²  O'Shea, Donal²  Small, Caroline²  Edwards, C.Mark B.²  Gunn, Irene² 

[1]Molecular Neuroendocrinology Unit, Rowett Research Institute, Aberdeen AB21 9SB, UK

[2]Department of Endocrinology and Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK

[3]Molecular Physiology Group, Rowett Research Institute, Aberdeen AB21 9SB, UK

关键词: Leptin;    GLP-1;    Exendin(9–39);    In situ hybridization;    Nucleus of the solitary tract;    Feeding;    ARC;    arcuate nucleus;    CC;    central canal;    c-FLI;    c-Fos-like immunoreactivity;    CNS;    central nervous system;    CRH;    corticotrophin releasing hormone;    GLP-1;    glucagon-like peptide-1 (7–36) amide;    GLP-1-IR;    GLP-1-like immunoreactivity;    ICV;    intracerebroventricular;    NPY;    neuropeptide Y;    NTS;    nucleus of the solitary tract;    OB-Rb;    long isoform of leptin receptor;    PCR;    polymerase chain reaction;    PVN;    paraventricular nucleus;   

DOI  :  10.1016/S0014-5793(97)01103-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The adipose tissue hormone, leptin, and the neuropeptide glucagon-like peptide-1 (7–36) amide (GLP-1) both reduce food intake and body weight in rodents. Using dual in situ hybridization, long isoform leptin receptor (OB-Rb) was localized to GLP-1 neurons originating in the nucleus of the solitary tract. ICV injection of the specific GLP-1 receptor antagonist, exendin(9–39), at the onset of dark phase, did not affect feeding in saline pre-treated controls, but blocked the reduction in food intake and body weight of leptin pre-treated rats. These findings suggest that GLP-1 neurons are a potential target for leptin in its control of feeding.

【 授权许可】

Unknown