Annexin I targets S100C to early endosomes

FEBS Letters

Seemann, Joachim¹  Weber, Klaus¹  Gerke, Volker¹ 

[1] Department of Biochemistry, Max Planck Institute for Biophysical Chemistry, D-37070 Göttingen, Germany

关键词: Annexin;    Ca2+ binding protein;    EF hand;    Endocytosis;   

DOI  :  10.1016/S0014-5793(97)00911-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Immunofluorescence and subcellular fractionation localize annexin I and the EF hand protein S100C to the same membranous structures which in part correspond to transferrin receptor-positive endosomes. The association of S100C with endosomal membranes is strictly dependent on annexin I binding since a D91stop–S100C mutant protein, in which the residues essential for annexin I binding have been removed, fails to co-localize with membraneous structures. This indicates that annexin I and S100C form a complex in vivo and that the endosomal localization of this complex is mediated through an interaction of annexin I with the endosomal membrane.

【 授权许可】

Unknown