Effects of melatonin in isolated rat papillary muscle

FEBS Letters

Abete, Pasquale¹  Cacciatore, Francesco¹  Napoli, Claudio¹  Calabrese, Claudio¹  Rengo, Franco¹  Bianco, Sabatino¹  Ferrara, Nicola¹ 

[1] Cattedra di Geriatria, Istituto di Medicina Interna Cardiologia e Chirurgia Cardiovascolare `Federico II', University of Naples, Via S. Pansini 80131, Naples, Italy

关键词: Melatonin;    Adreno-receptors;    Myocardial contractility;    Isoproterenol;    Calcium;    N-Acetyltryptamine;    Forskolin;    Papillary muscle;   

DOI  :  10.1016/S0014-5793(97)00749-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In conclusion, we found that melatonin possess anti-adrenergic effect in isolated rat papillary muscle. This phenomenon was abolished in the presence of its receptor antagonist N-acetyltryptamine demonstrating that melatonin operates through a specific cardiac receptor. The reduction of contractility increase, induced by forskolin-stimulated adenylate cyclase, shows that melatonin may act through a reduction of cyclic AMP accumulation.

【 授权许可】

Unknown