Tissue‐specific expression of the human laminin α5‐chain, and mapping of the gene to human chromosome 20q13.2‐13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation

FEBS Letters

Wewer, Ulla M.¹  Albrechtsen, Reidar¹  Durkin, Marian E.¹  Loechel, Frosty¹  Mattei, Marie-Geneviève²  Gilpin, Brent J.¹ 

[1] Institute of Molecular Pathology, University of Copenhagen, Frederik V's vej 11, DK-2100 Copenhagen, Denmark;Faculté de Médicine de la Timone, INSERM U406, 13385 Marseilles, France

关键词: Basement membrane;    cDNA cloning;    Gene mapping;    Laminin;   

DOI  :  10.1016/S0014-5793(97)00686-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To investigate the function of the laminin α5-chain, previously identified in mice, cDNA clones encoding the 953-amino-acid carboxy terminal G-domain of the human laminin α5-chain were characterized. Northern blot analysis showed that the laminin α5-chain is expressed in human placenta, heart, lung, skeletal muscle, kidney, and pancreas. The human laminin α5-chain gene (LAMA5) was assigned to chromosome 20q13.2-q13.3 by in situ hybridization, and the mouse gene (Lama5) was mapped by linkage analysis to a syntonic region of distal chromosome 2, close to the locus for the ragged (Ra) mutation.

【 授权许可】

Unknown