Differential effects of five types of antipathogenic plant peptides on model membranes

FEBS Letters

Caaveiro, José Manuel M¹  Goñi, Félix M¹  González-Mañas, Juan M¹  Garcı́a-Olmedo, Francisco²  Molina, Antonio²  Rodrı́guez-Palenzuela, Pablo² 

[1] Grupo Biomembranas (Unidad Asociada al CSIC), Departamento de Bioquı́mica, Universidad del Paı́s Vasco, Aptdo. 644, 48080 Bilbao, Spain;Laboratorio de Bioquı́mica y Biologı́a Molecular, ETS Ingenieros Agrónomos — UPM, 28040 Madrid, Spain

关键词: Thionin;    Defensin;    Lipid transfer protein;    Plant pathogen;    Biomembrane;   

DOI  :  10.1016/S0014-5793(97)00613-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of five antipathogenic plant peptides, wheat α-thionin, potato PTH1 defensin, barley LTP2 lipid transfer protein, and potato tuber DL1 and DL2 defensins, have been tested against phospholipid vesicles (liposomes). Wheat thionin very actively induces aggregation and leakage of negatively charged vesicles. LTP2 displays the same activities, although to a limited extent. Under certain conditions PTH1 and DL2 induce vesicle aggregation, but not leakage. Potato defensin DL1 failed to show any effect on liposomes. The same peptides have been assayed against a plant pathogenic bacterium, both the membrane-active and -inactive compounds having efficient antibacterial action.

【 授权许可】

Unknown