Suppression of HIV‐1 transcription by β‐chemokines RANTES, MIP1‐α, and MIP‐1β is not mediated by the NFAT‐1 enhancer element

FEBS Letters

Handen, Jeffrey S¹  Rosenberg, Helene F¹ 

[1] Laboratory of Host Defenses, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

关键词: HIV-1;    Long terminal repeat;    β-Chemokine;    Transcription;   

DOI  :  10.1016/S0014-5793(97)00654-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Soluble factors derived from human CD8+ T-lymphocytes inhibit HIV-1 replication by suppressing transcription from the viral long terminal repeat (LTR), an effect shown to be mediated in part by an NFAT-1 enhancer sequence. We show here that the CD8+ derived β-chemokines, RANTES, MIP1-α, and MIP-1β, known suppressors of HIV-1 replication in human peripheral blood mononuclear cells, can suppress transcription from the HIV-1 LTR in transient transfection assays in cells of the Jurkat (acute T leukemia) line. Surprisingly, the suppression mediated by these β-chemokines persisted in the absence of an intact NFAT-1 element, suggesting that there are at least two classes of HIV-1 suppressor factors — NFAT-1-dependent and NFAT-1-independent factors — produced by CD8+ T-lymphocytes.

【 授权许可】

Unknown