In search of a function for the Ras‐like GTPase Rap1

FEBS Letters

Reedquist, Kris¹  Bos, Johannes L¹  Franke, Barbara¹  M'Rabet, Laura¹  Zwartkruis, Fried¹ 

[1] Laboratory for Physiological Chemistry, Utrecht University, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands

关键词: Rap1;    Activation;    GTPase;   

DOI  :  10.1016/S0014-5793(97)00324-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rap1 (Krev-1) is a small GTPase first identified as a transformation suppressor of K-ras. This GTPase is very similar to Ras, particularly in the effector region, but its function is still elusive. Recent progress in the search for Rap1 function has come from the development of a novel assay to measure Rap1 activation. Using this assay activation of Rap1 was observed in human platelets and neutrophils after stimulation with various agonists. We speculate that Rap1 plays a role in one of the specialised functions of these cells.

【 授权许可】

Unknown