Lysophosphatidic acid as a phospholipid mediator: pathways of synthesis

FEBS Letters

Gueguen, Geneviève¹  Mauco, Gérard¹  Fauvel, Josette¹  Gaigé, Bernadette¹  Le Balle, François¹  Fourcade, Olivier¹  Chap, Hugues¹  Salles, Jean-Pierre¹  Gassama-Diagne, Ama¹  Simon, Marie-Françoise¹  Gaits, Frédérique¹ 

[1] Institut Fédératif de Recherche en Immunologie Cellulaire et Moléculaire, Université Paul Sabatier and Centre Hospitalo-Universitaire de Toulouse, INSERM Unité 326, Phospholipides Membranaires, Signalisation Cellulaire et Lipoprotéines, Hôpital Purpan, 31059 Toulouse, France

关键词: Lysophosphatidic acid;    Phospholipase A2;    Phospholipase A1;    Diacylglycerol lipase;    Platelets;    LPA;    lysophosphatidic acid;    PA;    phosphatidic acid;    DAG;    diacylglycerol;    MAG;    monoacylglycerol;    PLA1;    phospholipase A1;    PLA2;    phospholipase A2;    snpPLA2;    secretory non-pancreatic phospholipase A2;    PLC;    phospholipase C;   

DOI  :  10.1016/S0014-5793(97)00411-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

From very recent studies, including molecular cloning of cDNA coding for membrane receptors, lysophosphatidic acid (LPA) reached the status of a novel phospholipid mediator with various biological activities. Another strong argument supporting this view was the discovery that LPA is secreted from activated platelets, resulting in its appearance in serum upon blood coagulation. The metabolic pathways as well as the enzymes responsible for LPA production are poorly characterized. However, a survey of literature data indicates some interesting issues which might be used as the basis for further molecular characterization of phospholipases A able to degrade phosphatidic acid.

【 授权许可】

Unknown