Molecular diversity of sphingolipid signalling

FEBS Letters

Jakobs, Karl H¹  Meyer zu Heringdorf, Dagmar¹  van Koppen, Chris J¹ 

[1] Institut für Pharmakologie, Universität GH Essen, Hufelandstrasse 55, D-45122 Essen, Germany

关键词: Sphingolipid;    Sphingosine 1-phosphate;    Sphingosylphosphorylcholine;    G protein-coupled receptor;    Signal transduction;    SPP;    sphingosine 1-phosphate;    SPPC;    sphingosylphosphorylcholine;    GPS;    glucopsychosine;    DHS;    dl-threo-dihydrosphingosine;    LPA;    lysophosphatidic acid;    PTX;    pertussis toxin;    PDGF;    platelet-derived growth factor;   

DOI  :  10.1016/S0014-5793(97)00320-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Sphingolipid breakdown products are now being recognized to play a dual role in cellular signalling, acting as intracellular as well as extracellular signalling molecules. Both types of action may even be found with one sphingolipid species. The recent demonstration of G protein-coupled receptors with high affinity for sphingosine 1-phosphate and sphingosylphosphorylcholine has been followed by the discovery of several novel sphingolipid actions, such as regulation of heart rate, oxidative burst, neurite retraction or platelet activation. Ligand profiles and concentration-response relationships suggest the existence of putative sphingolipid receptor subtypes. Against this background, several observations on supposed sphingolipid second messenger actions deserve a new evaluation.

【 授权许可】

Unknown