The arrangement of the transmembrane helices in the secretin receptor family of G‐protein‐coupled receptors

FEBS Letters

Donnelly, Dan¹ 

[1] Department of Pharmacology, University of Leeds, Leeds LS2 9JT, UK

关键词: G-protein-coupled receptor;    Secretin;    Rhodopsin;    Periodicity;    Model;    α-Helix;   

DOI  :  10.1016/S0014-5793(97)00546-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The members of the secretin receptor family of G-protein-coupled receptors share no significant sequence similarity to the more familiar rhodopsin-like family. However, multiple sequence alignment analysis reveals seven hydrophobic regions with significant α-helical periodicity. Residues that are likely to be buried on the interior of the helical bundle and others that are likely to contact the lipid bilayer are identified. A predicted arrangement of the helical bundle is described in which, by comparison with the arrangement in the rhodopsin family, helices 2 and 7 are more buried within the bundle while helix 3 is more exposed to the lipid bilayer.

【 授权许可】

Unknown