Non‐iron porphyrins inhibit β‐haematin (malaria pigment) polymerisation

FEBS Letters

Monti, Diego¹  Basilico, Nicoletta³  Taramelli, Donatella³  Olliaro, Piero² 

[1] Dipartimento di Chimica Organica e Industriale, Università di Milano, CSSON, CNR, Via Venezian 21, Milan, Italy;UNDP/ WorldBank/ WHO Special Programme for Research and Training in Tropical Diseases (TDR), Geneva, Switzerland;Instituto di Microbiologia Medica, Università di Milano, Via Pascal 36, 20133 Milan, Italy

关键词: Malaria;    Haem;    Haemozoin;    β-Haematin;    Protoporphyrin IX;    Haematoporphyrin;   

DOI  :  10.1016/S0014-5793(97)00533-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Infrared spectroscopy was used to evaluate the effect of non-iron porphyrins (protoporphyrin IX and haematoporphyrin) on haematin polymerisation to β-haematin at acidic pH. Both molecules effectively inhibited the reaction, with haematoporphyrin 6 times as active as protoporphyrin IX. We postulated that the interaction between the π electron system of porphyrin rings leads to the formation of π–π adducts, which inhibit polymer elongation in the same way as antimalarial drugs (e.g., chloroquine); the presence of hydroxyl groups able to bind haem iron enhances activity.

【 授权许可】

Unknown