Different utrophin and dystrophin properties related to their vascular smooth muscle distributions

FEBS Letters

Robert, Agnès¹  Mornet, Dominique¹  Rivier, François¹  Hugon, Gérald¹ 

[1] Pathologie Moleculaire du Muscle, INSERM U 300, Bât K, Faculté de Pharmacie, 34060 Montpellier, Cedex, France

关键词: DRP1;    dystrophin-related protein number 1;    DRP2;    dystrophin-related protein number 2;    Dp 71;    dystrophin protein with 71 kDa molecular mass;   

DOI  :  10.1016/S0014-5793(97)00398-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Monoclonal antibodies used to distinguish between dystrophin and utrophin were systematically applied to skeletal muscles containing arteries and veins. Small arteries were found to contain long forms of both utrophin and dystrophin, while small veins contained only long forms of utrophin. In addition, all sizes of vascular smooth muscles were demonstrated to contain another related M _r 80 kDa protein (possibly a short utrophin transcript). Regardless of their tissue distributions, we assumed that each of these molecules had distinct properties, i.e. dystrophin with a mechanical function and utrophin with an architectural function. This difference in the roles of dystrophin and utrophin could reduce the efficiency of protection against muscle membrane degeneration when utrophin overexpression is programmed.

【 授权许可】

Unknown