Mitochondrial fatty acid synthesis: a relic of endosymbiontic origin and a specialized means for respiration

FEBS Letters

Massow, Michael¹  Weiss, Hanns¹  Schneider, Regina¹  Brors, Benedikt¹ 

[1]Institut für Biochemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstr. 1/Geb. 26.42.03, 40225 Düsseldorf, Germany

关键词: Fatty acid synthesis;    Acyl carrier protein;    Mitochondrial respiration;    Mitochondrial biogenesis;    Lipid repair;    NADH:ubiquinone oxidoreductase (EC 1.6.99.3);   

DOI  :  10.1016/S0014-5793(97)00360-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Genes that encode mitochondrial homologues to the bacterial enzymes of fatty acid synthesis were found in various eukaryotic species. Inactivation of these genes leads to a disturbed mitochondrial respiration and an increase in mitochondrial lysophospholipids. We postulate that there is a mitochondrial biosynthetic system providing fatty acids for phospholipid repair. The mitochondrial acyl carrier protein may also play another role, supporting the formation of the respiratory NADH:ubiquinone oxidoreductase.

【 授权许可】

Unknown