A structural tree for proteins containing 3β‐corners

FEBS Letters

Efimov, A.V.¹ 

[1] Institute of Protein Research, Russian Academy of Sciences, 142292 Pushchino, Moscow Region, Russia

关键词: Protein classification;    Protein structure comparison;    Stepwise folding;    Structural motif;    Structural similarity;   

DOI  :  10.1016/S0014-5793(97)00296-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A structural tree for β-proteins with predominantly orthogonal β-sheet packing has been constructed. The 3β-corner, a structural motif that recurs in proteins of this class, is taken as a root structure of the tree. The 3β-corner can be represented as a triple-stranded β-sheet folded on to itself so that its two β-β-hairpins are packed approximately orthogonally in different layers and the central strand bends by ∼90° in a right-handed direction when passing from one layer to the other. The larger protein structures are obtained by stepwise addition of β-strands to the root 3β-corner taking into account a restricted set of rules inferred from known principles of protein structure. The protein structures that can be obtained in this way are grouped into one structural class and those found in branches of the structural tree into subclasses.

【 授权许可】

Unknown