Sensing by intrahepatic muscarinic nerves of a portal‐arterial glucose concentration gradient as a signal for insulin‐dependent glucose uptake in the perfused rat liver

FEBS Letters

Jungermann, Kurt¹  Stümpel, Frank¹ 

[1] Institut für Biochemie und Molekulare Zellbiologie, Georg-August-Universität, Humboldtallee 23, 37073 Göttingen, Germany

关键词: Liver metabolism;    Insulin;    Bivascular liver perfusion;    Muscarinic nerve;    PV;    portal vein;    HA;    hepatic artery;    IVC;    inferior vena cava;   

DOI  :  10.1016/S0014-5793(97)00254-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In vivo, insulin increases net hepatic glucose uptake efficiently only in the presence of a portal-arterial glucose gradient. In isolated perfused rat livers supplied with a glucose gradient (portal 10 mM/arterial 5 mM) insulin-induced glucose uptake was blocked by atropine; in livers not supplied with the gradient (portal=arterial 5 mM) insulin-dependent glucose uptake was elicited by acetylcholine. Apparently, the gradient was sensed and transformed into a metabolic signal by intrahepatic nerves, releasing acetylcholine to muscarinic receptors.

【 授权许可】

Unknown