Ubiquitination of Na,K‐ATPase α1 and α2 subunits

FEBS Letters

Guidotti, Guido¹  Coppi, Maddalena Virginia¹ 

[1] Department of Cellular and Molecular Biology, Fairchild Biochemistry Building, Harvard University, 7 Divinity Ave., Cambridge, MA 02138, USA

关键词: Na;    K-ATPase;    Ubiquitin;    Polytopic integral membrane protein;    COS-7 cell;    α subunit;    Proteasome;    CFTR;    cystic fibrosis transmembrane conductance regulator;   

DOI  :  10.1016/S0014-5793(97)00182-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Na,K-ATPase, an essential transporter of mammalian cells, is an oligomeric transmembrane protein composed of two subunits, α and β, of which there are several isoforms. In this study, we demonstrate that the α1 and α2 isoforms of the Na,K-ATPase α subunit are modified by the covalent attachment of ubiquitin polymers in COS-7 cells. We propose that polyubiquitination of the Na,K-ATPase α subunit may play a role in regulating its degradation.

【 授权许可】

Unknown