Analysis of the contribution of the hinge region of human neutrophil collagenase (HNC, MMP‐8) to stability and collagenolytic activity by alanine scanning mutagenesis

FEBS Letters

Tschesche, Harald¹  Smith, Bryan³  Docherty, Andrew J.P³  Murphy, Gillian²  Knäuper, Vera² 

[1]Department of Biochemistry I, University of Bielefeld, 33501 Bielefeld, Germany

[2]Department of Cell and Molecular Biology, Strangeways Research Laboratory, Worts' Causeway, Cambridge CB1 4RN, UK

[3]Department of Oncology, Celltech Ltd., Slough SL1 4EN, UK

关键词: FC;    fibroblast collagenase;    HNC;    human neutrophil collagenase;    MMP;    matrix metalloproteinase;    APMA;    p-aminophenyl mercuric acetate;    Mca;    (7-methoxycoumarin-4-yl)acetyl;    Dpa;    N-3-(2;    4-dinitrophenyl)-l-2;    3-diaminopropionyl;    McaPLGLDpaAR;    Mca–Pro–Leu–Gly–Leu–Dpa–Ala–Arg–NH2;    SL;    stromelysin;    SL-2;    stromelysin-2;   

DOI  :  10.1016/S0014-5793(97)00158-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

© 1997 Federation of European Biochemical Societies.

【 授权许可】

Unknown