Modified low density lipoprotein delivers substrate for ceramide formation and stimulates the sphingomyelin‐ceramide pathway in human macrophages

FEBS Letters

Hack, Volker⁴  Hermetter, Albin¹  Deigner, Hans P²  Rußwurm, Stefan⁵  Claus, Ralf²  Metz, Jürgen⁶  Nauen, Olaf²  Daniel, Volker³  Gehrke, Christoph²  Kinscherf, Ralf⁶ 

[1] Institut für Biochemie und Lebensmittelchemie, Technische Universität, 8010 Graz, Austria;Pharmazeutisch-Chemisches Institut, Universität Heidelberg, 69120 Heidelberg, Germany;Institut für Immunologie, Universität Heidelberg, 69120 Heidelberg, Germany;Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany;Klinikum der Friedrich-Schiller-Universität Jena, 07740 Jena, Germany;Institut für Anatomie und Zellbiologie III, Universität Heidelberg, 69120 Heidelberg, Germany

关键词: Macrophage;    Lipoprotein;    Oxidized LDL;    Sphingomyelin;    Ceramide;    acLDL;    acetylated low density lipoprotein;    BODIPY-FL-C5-SM;    N-(4;    4-difluoro-5;    7-dimethyl-4-bora-3a;    4a-diaza-s-indacene-3-pentanoyl)-sphingosylphosphocholine/sphingomyelin;    BODIPY-FL-C5-CA;    N-(4;    4-difluoro-5;    7-dimethyl-4-bora-3a;    4a-diaza-s-indacene-3-pentanoyl)-sphingosine/ceramide;    CA;    ceramide;    C2-CA;    N-acetyl-ceramide;    N-acetyl-d-erythrosphingosine;    DAG;    diacylglycerol;    EC;    human umbilical endothelial cell(s);    EC-LDL;    LDL oxidized by endothelial cells;    HBMC;    human blood monocytes derived macrophages;    oxLDL;    oxidized LDL;    PBS;    phosphate-buffered sodium chloride solution;    SM;    N-acylsphingosin-1-phosphocholine;    sphingomyelin;    SMase;    sphingomyelinase(s);    sphingomyelin phosphodiesterase;    TLC;    thin-layer chromatography;   

DOI  :  10.1016/S0014-5793(97)00157-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

© 1997 Federation of European Biochemical Societies.

【 授权许可】

Unknown