Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin‐treated obese (ob/ob) and cold‐exposed lean mice

FEBS Letters

Moar, Kim M¹  Rayner, D.Vernon²  Hoggard, Nigel²  Mercer, Julian G¹  Trayhurn, Paul² 

[1] Molecular Neuroendocrinology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK;Molecular Physiology Group, Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK

关键词: Leptin receptor mRNA;    Arcuate nucleus;    Ventromedial nucleus;    Obesity;    Leptin injection;    Cold exposure;   

DOI  :  10.1016/S0014-5793(96)01525-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Leptin receptor gene expression has been measured in arcuate and ventromedial hypothalamic nuclei. Receptor mRNA in both hypothalamic areas was higher in obese mice than in lean littermates. Twice daily leptin administration for 7 days profoundly affected food intake, reduced leptin receptor mRNA in the arcuate nucleus, and had a similar effect on neuropeptide Y gene expression. A single leptin injection was ineffective. Exposure of lean mice to cold for 24 h caused an induction of leptin receptor and NPY mRNA which was normalized when animals were returned to the warm. Regulation of receptor gene expression may be an important component in the reading of the leptin signal.

【 授权许可】

Unknown