Overlapping distribution of KATP channel‐forming Kir6.2 subunit and the sulfonylurea receptor SUR1 in rodent brain

FEBS Letters

Ecke, Claudia³  Karschin, Andreas³  Ashcroft, Frances M¹  Karschin, Christine² 

[1] University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK;Max Planck Institute for Experimental Medicine, 37077 Göttingen, Germany;Max Planck Institute for Biophysical Chemistry, Molecular Neurobiology of Signal Transduction, 37077 Göttingen, Germany

关键词: KATP channel;    Inward rectifier;    Sulfonylurea receptor;    In situ hybridization;    ABC transporter;   

DOI  :  10.1016/S0014-5793(96)01438-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

ATP-sensitive K⁺ channels comprise a complex of at least two proteins: a member of the inwardly rectifying Kir6 family (e.g. Kir6.2) and a sulphonylurea receptor (e.g. SUR1) which belongs to the ATP-binding cassette (ABC) superfamily. Using specific radiolabeled antisense oligonucleotides, the cellular localization of both mRNAs was investigated in the rodent brain by in situ hybridization. The distribution of both transcripts was widespread throughout the brain and showed a high degree of overlap with peak expression levels in the hippocampus, neocortex, olfactory bulb, cerebellum, and several distinct nuclei of the midbrain and brainstem, indicating their important role in vital brain function.

【 授权许可】

Unknown