Overlapping and distinct signals through leptin receptor (OB‐R) and a closely related cytokine signal transducer, gp130

FEBS Letters

Nakashima, Kinichi¹  Taga, Tetsuya¹  Narazaki, Masashi¹ 

[1] Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565, Japan

关键词: Leptin;    OB-R;    gp130;    STAT3;    p42ERK2;    SHP-2;    OB-R;    obese receptor;    db;    diabetes mutant;    IL-6;    interleukin-6;    STAT;    signal transducer and activator of transcription;    SHP-2;    Src homology domain 2 containing protein tyrosine phosphatase 2;    p42ERK2;    extracellular signal-regulated protein kinases 2;   

DOI  :  10.1016/S0014-5793(96)01430-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The structure of leptin receptor (OB-R) is highly homologous to that of gp130, the common signal transducing receptor component for the interleukin-6 family of cytokines. Based on this structural similarity, we examined signaling processes initiated by OB-R in comparison with those by gp130. Stimulation of either a long form of OB-R or gp130 led to tyrosine phosphorylation of STAT3, whereas stimulation of the truncated form of OB-R that is predominantly expressed in db/db mice failed to do so. Stimulation of the long form OB-R did not induce tyrosine phosphorylation of a Src homology domain 2 containing protein tyrosine phosphatase, SHP-2, while stimulation of gp130 did. In contrast, activation of p42^ERK2 is mediated by either the long form OB-R or gp130. Two closely related molecules, OB-R and gp130, thus appear to mediate overlapping but distinct signaling procedures.

【 授权许可】

Unknown