Expression of a 26S proteasome ATPase subunit, MS73, in muscles that undergo developmentally programmed cell death, and its control by ecdysteroid hormones in the insect Manduca sexta

FEBS Letters

Bussell, K²  Mayer, R.J¹  Billett, M.A¹  Dawson, S.P¹  Reynolds, S.E²  Löw, P² 

[1]Department of Biochemistry, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK

[2]School of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK

关键词: Proteasome;    ATPase;    Programmed cell death;    Manduca sexta;    Ecdysteroid agonist;    RH-5849;   

DOI  :  10.1016/S0014-5793(96)01413-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

MS73, an ATPase regulatory subunit of the 26S proteasome in the moth Manduca sexta, is shown to be expressed at a high level only in muscles that are undergoing developmentally programmed cell death, or which are destined to do so. The amount of MS73 is increased by more than two-fold just before death in each of three different muscles that die at different times, under different developmental controls. An ecdysteroid (moulting hormone) agonist, RH-5849, that prevents the occurrence of programmed cell death in two of these muscles also prevents the normally occurring rise in level of MS73 in these muscles. This evidence is consistent with a role for MS73 in programmed cell death.

【 授权许可】

Unknown