Structure and distribution of a broadly expressed atypical sodium channel

FEBS Letters

Akopian, Armen N¹  Souslova, Veronika¹  Wood, John N¹  Sivilotti, Lucia¹ 

[1] Department of Anatomy and Developmental Biology, University College, Gower Street, London WC1E 6BT, UK

关键词: Dorsal root ganglion;    Voltage-gated sodium channel;    cDNA cloning;   

DOI  :  10.1016/S0014-5793(96)01389-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A cDNA clone isolated from a rat dorsal root ganglion library encodes a 195 kDa voltage-gated sodium channel-like protein (SCL-11) with homology to the mouse (87%) and human (72%) atypical Na⁺ channels and rat partial clone NaG (98%). Two dominant mRNAs of 4.5 and 7 kb are expressed. The transcripts are present in lung, Schwann cells, pituitary and tissues containing smooth muscle cells. No functional channels could be detected on oocyte injection with cRNA, consistent with the absence of structural features necessary for voltage-gated sodium channel activity.

【 授权许可】

Unknown