Short photoperiod reduces leptin gene expression in white and brown adipose tissue of Djungarian hamsters

FEBS Letters

Heldmaier, Gerhard¹  Dickopp, Alexandra¹  Klingenspor, Martin¹  Klaus, Susanne¹ 

[1] Fachbereich Biologie/Zoologie, Philipps Universität, Karl v. Frisch Straße, D-35043 Marburg, Germany

关键词: Leptin;    obese gene;    Seasonal acclimatization;    Brown and white adipose tissue;    Djungarian hamster;    BAT;    brown adipose tissue;    COX;    cytochrome c oxidase activity;    iWAT;    inguinal white adipose tissue;    LD;    long day;    LPL;    lipoprotein lipase;    SD;    short day;    UCP;    uncoupling protein;    WAT;    white adipose tissue;   

DOI  :  10.1016/S0014-5793(96)01343-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Leptin gene expression in white (WAT) and brown adipose tissue (BAT) of the Djungarian hamster (Phodopus sungorus) was analyzed during seasonal acclimatization. Leptin gene expression in WAT was markedly reduced during winter, independent of changes in environmental temperature. Exposure to artificial short photoperiod also decreased leptin gene expression in WAT as well as in BAT. Although specific leptin gene expression was lower in BAT, total depot expression was as high as in WAT depots, due to higher RNA content of BAT. Our results indicate that there is significant leptin synthesis in brown fat and that leptin might be involved in photoperiod mediated seasonal adaptations of mammals independent of food deprivation or overfeeding.

【 授权许可】

Unknown