The MAP kinase cascades are activated during post‐ischemic liver reperfusion

FEBS Letters

Bernelli-Zazzera, Aldo¹  Piccoletti, Roberta¹  Bendinelli, Paola¹  Maroni, Paola¹ 

[1] Istituto di Patologia Generale dell'Università degli Studi di Milano, Centro di Studio sulla Patologia Cellulare del CNR, Via Mangiagalli 31, 20133 Milan, Italy

关键词: Liver;    Post-ischemic reperfusion;    MAPK cascade;    Signal transduction;   

DOI  :  10.1016/S0014-5793(96)01228-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have investigated the involvement of MAP kinase cascades in the response of the liver to post-ischemic reperfusion. Both JNKs and ERKs are activated but the duration and magnitude of the increase in their activities appear to be different. JNK activation is more marked but shorter than that of ERKs. The increase observed in the phosphotyrosine content of the 52 kDa Shc protein, accompanied by an increased amount of co-immunoprecipitated Grb2, and the activation of Raf-1 kinase provide evidence of the involvement of a Ras-Raf-dependent pathway, with a time course that is similar to that of ERK activation. The treatment of rats with IL-1 receptor antagonist modified all of the described effects, suggesting that IL-1 plays a role in the response of the liver to reperfusion.

【 授权许可】

Unknown