Studies on endothelin receptors in the zonae fasciculata/reticularis of the rat adrenal cortex: contrast with the zona glomerulosa

FEBS Letters

Hinson, J.P.¹  Cameron, L.A.¹  Puddefoot, J.R.¹  Kapas, S.¹ 

[1] Department of Biochemistry, Faculty of Medical Sciences, Queen Mary and Westfdeld College, Mile End Road, London E1 4NS, UK

关键词: Aldosterone;    Corticosterone;    Endothelin receptor;    Zona glomerulosa;    Adrenal;   

DOI  :  10.1016/S0014-5793(96)01133-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study investigated the ET _A and ET _B receptor subtypes in rat adrenal cortex. The ET _A antagonist, BQ-123, inhibited the zona glomerulosa (zg), but not the inner zone (iz) response to ET-1. RES-701-1, the ET _B antagonist, abolished the iz response to ET-1, but had less effect on the zg. [¹²⁵I]ET-1 binding studies revealed two receptor subtypes in both zones, with ET _A predominating in the zg, and ETB in the iz. These data suggest that the ET _A subtype is functionally more important in the zg while the ET _B receptor is the major subtype in the inner zones.

【 授权许可】

Unknown