Evidence for a novel regulatory pathway activated by (carba)prostacyclin in preadipose and adipose cells

FEBS Letters

Aubert, Jérôme¹  Ailhaud, Gérard¹  Negrel, Raymond¹ 

[1]Centre de Biochimie du CNRS (UMR 134), Université de Nice-Sophia Antipolis, Faculté des Sciences, Parc Valrose, 06108 Nice Cedex 2, France

关键词: Prostanoid;    Prostacyclin;    Angiotensinogen;    Fatty acid binding protein;    Peroxisome proliferator activated receptor;    Adipose tissue;   

DOI  :  10.1016/S0014-5793(96)01152-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Prostacyclin, one of the major prostanoids generated in adipose tissue, has been previously described as an autocrine/ paracrine adipogenic effector, acting, in preadipose cells, by means of cAMP and free Ca²⁺ as cell surface receptor-mediated messengers. The present study presents evidence for the first time that its stable analogue, carbaprostacyclin, is unique among prostanoids in regulating the expression of two differentiation-dependent genes in preadipose and adipose cells in a way distinct from that elicited by its cell surface receptor. This regulation is likely mediated by some member(s) of the peroxisome proliferator-activated receptor family and suggests that prostacyclin behaves as an intracrine effector of adipose cell differentiation.

【 授权许可】

Unknown