A molecular model for human Big‐Endothelin‐1 (Big ET‐1)

FEBS Letters

Peto, Heather¹  Janes, Robert W.¹  Wallace, B.A.¹  Corder, Roger² 

[1] Department of Crystallography, Birkbeck College, University of London, London, WC1E 7HX, UK;The William Harvey Research Institute, St. Bartholomew's Medical College, Chatterhouse Square, London, EC1M 6BQ, UK

关键词: Threading algorithm;    Endothelin converting enzyme;    Crystal structure;    Rational drug design;    Endothelin precursor;   

DOI  :  10.1016/0014-5793(96)00951-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A molecular model has been developed for human Big Endothelin-1, which is the immediate precursor to the potent vasoconstrictor polypeptide endothelin-1 and the target of the highly specific endothelin converting enzyme. This model is produced by a threading algorithm protocol and is consistent with all the currently available structural and biochemical data for this molecule.

【 授权许可】

Unknown