Gcm1, a mammalian homolog of Drosophila Glial Cells Missing

FEBS Letters

Gilbert, Debra J.²  Jenkins, Nancy A.²  Altshuller, Yelena¹  Copeland, Neal G.²  Frohman, Michael A.¹ 

[1] Department of Pharmacological Sciences and Institute for Cell and Molecular Biology, State University of New York, Stony Brook, NY 11794-8651, USA;Mammalian Genetics Laboratory, ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, Frederick, MD 21702, USA

关键词: Gcm;    Glia;    Glial cells missing;    Gliogenesis;    mGCM1;    Neurogenesis;   

DOI  :  10.1016/0014-5793(96)00890-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Differentiation of glia (astrocytes and oligodendrocytes) in Drosophila requires the gene glial cells missing (gcm), which controls lineage determination. In the absence of gcm, neuroglia progenitors exclusively differentiate into neurons, instead of into both neurons and glia. In contrast, ectopic overexpression of gcm causes uniform differentiation of the neuroglia progenitors into glia. Glial and neuronal cells in vertebrates similarly derive from neuroblast progenitors. To investigate vertebrate glial formation, we have identified, cloned, and chromosomally mapped a mammalian gcm homolog. Mouse Gcm1 demonstrates extensive similarity to Drosophila gcm but is expressed at very low levels during neuro- and gliogenesis.

【 授权许可】

Unknown