Activation of the lamin A gene during rat liver development

FEBS Letters

Fatima, Soghra¹  Hamid, Q.Anwar¹  Parnaik, Veena K.¹  Thanumalayan, Subramonian¹ 

[1] Centre for Cellular and Molecular Biology, Hyderabad 500 007, India

关键词: Lamin A gene;    Nuclear lamina;    Liver development;   

DOI  :  10.1016/0014-5793(96)00802-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have studied the regulation of expression of the A-type lamins, which are constituents of the nuclear lamina. During rat liver development, high levels of lamin A and C mRNAs were observed in 15-day fetal liver but were barely detectable in the adult. The chromatin conformation of the lamin A gene was sensitive to DNase I in 15-day fetal liver but became mostly insensitive in the adult. Lamin A and C proteins could be detected in fetal liver and persisted in the adult. Our evidence suggests that the lamin A gene is actively transcribed early in liver differentiation and its activity declines considerably in adult liver.

【 授权许可】

Unknown