Identification of a novel endogenous memory facilitating cyclic dipeptide cyclo‐prolylglycine in rat brain

FEBS Letters

Voronina, T.A²  Akparov, V.Kh¹  Ostrovskaya, R.U²  Seredenin, S.B²  Gudasheva, T.A²  Zherdev, V.P²  Skoldinov, S.P²  Rozantsev, G.G²  Boyko, S.S² 

[1] State Institute of Genetics and Selection of Industrial Microorganisms, 1-st Dorojny proezd, 1, Moscow, 113545 Russian Federation;Institute of Pharmacology, Russian Academy of Medical Science, Baltijskaya, 8, Moscow, 125315, Russian Federation

关键词: Cyclo-prolylglycine;    Endogenous cyclic dipeptide;    Memory facilitating substance;    AA;    antiamnesic activity;    amu;    atomic mass unit;    AVP;    arginine vasopressin;    FAB;    fast atom bombarding mass spectrometry;    GC;    gas chromatography;    GC-MS;    gas chromatography-mass spectrometry;    HPLC;    high-performance liquid chromatography;    MES;    maximal electroconvulsive shock;    MOPS;    3-morpholinopropanesulfonic acid;    PDAH;    pyrrolidino-[1;    2-a]-2;    6-diazacycloheptanedione-1;    5;    RIC;    relative ion current;    SIM;    selected ion monitoring;    UV;    ultraviolet;   

DOI  :  10.1016/0014-5793(96)00722-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Using high-performance liquid chromatography, gas-chromatography and chromato-mass spectrometry methods a novel endogenous cyclic dipeptide cyclo-prolylglycine was identified in rat brain. Its content according to gas chromatography is 2.8 ± 0.3 nmol/g wet brain. Synthetic cyclo-prolylglycine has demonstrated antiamnesic activity in the passive avoidance test in rats at a dose of 0.1 mg/kg i.p. Cyclic dipeptide cyclo-prolylglycine seems to be a memory facilitating substance and its presence in rat brain suggests the existence of a new mechanism of memory regulation.

【 授权许可】

Unknown