Membranotropic properties of the water soluble amino acid and peptide derivatives of fullerene C60

FEBS Letters

Vol'pin, Mark E.²  Kotelnikova, Raisa A.¹  Kotelnikov, Alexander I.¹  Kuleshova, Elena F.²  Romanova, Valentina S.²  Parnes, Zinaida N.²  Bogdanov, Guennady N.¹ 

[1] Institute of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region 142432, Russian Federation;Institute of Organoelement Compounds, Russian Academe of Sciences, Moscow, Russian Federation

关键词: Liposome;    Fullerene;    Fluorescence;    Triplet probe;    C60-AD;    water soluble amino acid derivatives of fullerene C60;    C60-A;    dl-alanine derivatives of C60;    C60-AA;    dl-alanyl-dl-alanine derivatives of C60;   

DOI  :  10.1016/0014-5793(96)00537-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The modifying effects of the products of the equimolar addition of dl-alanine and dl-alanyl-dl-alanine to fullerene C₆₀ on the structure and permeability of the lipid bilayer of phosphatidylcholine liposomes has been studied using the luminescence probe technique. It is shown that these water soluble amino acid and dipeptide derivatives of fullerene (C₆₀-AD) are quenchers of pyrene fluorescence and erythrosine phosphorescence of in both a water solution and liposomes. To study the permeability of the lipid bilayer a procedure based on the triplet probe technique has been developed. It has been found that the C₆₀-AD derivatives under study are able to localize inside the artificial membrane, to penetrate into the liposomes through the lipid bilayer and to perform activated transmembrane transport of bivalent metal ions.

【 授权许可】

Unknown