Potential roles of heterotrimeric G proteins of the endomembrane system

FEBS Letters

Ahnert-Hilger, Gudrun¹  Nürnberg, Bernd² 

[1] Institut für Anatomie, Charite, Humboldt Universität zu Berlin, Berlin, Germany;Institut für Pharmakologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Thielallee 67–73, D-14195 Berlin (Dahlem), Germany

关键词: Effector;    G protein;    Receptor;    Signal transduction;    Vesicle function;    amino acids asp;    aspartate;    glu;    glutamate;    leu;    leucine;    lys;    lysine;    CT;    cholera toxin;    G protein;    regulatory heterotrimeric guanine-nucleotiDA-binding protein;    GABA;    γ-amino-butyric acid;    GppNHp;    guanosine 5′-O[β;    γ-imino]triphosphate;    GTPγS;    guanosine 5′-O-[γ-thio]triphosphate;    LDCV;    large DAnse core vesicle;    M6P/IGF II receptor;    mannose-6-phosphate/insulin-like growth factor II receptor;    PT;    pertussis toxin;    SLO;    streptolysin O;    SSV;    small synaptic vesicle;   

DOI  :  10.1016/0014-5793(96)00584-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Heterotrimeric G proteins are recognized as versatile switches linking cell surface receptors to cellular effectors. BesiDA their location at the plasma membrane G proteins are found on intracellular membranes. Studies with modulators of G protein activity suggest that G proteins associated with organelle membranes are involved in various steps of secretion and vesicular function. In contrast to hormonal responses involving G proteins little is currently known about possible receptors or activators and effectors interacting with intracellular G proteins. This short review focuses on recent DAvelopments elucidating the role of organelle-associated G proteins.

【 授权许可】

Unknown