FEBS Letters | |
Bifurcated ubihydroquinone oxidation in the cytochrome bc 1 complex by proton‐gated charge transfer | |
Brandt, Ulrich1  | |
[1] Universitätsklinikum Frankfurt, Zentrum der Biologischen Chemie, Theodor-Stern-Kai 7, Haus 25B, D-60590 Frankfurt am Main, Germany | |
关键词: Cytochrome bc 1 complex; Ubiquinone; Q-cycle; Charge-transfer mechanism; Deprotonation; | |
DOI : 10.1016/0014-5793(96)00436-X | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The unique bifurcation of electron flow at the ubihydroquinone-oxidation center of the cytochrome bc 1 complex is the energy-conserving reaction of the protonmotive Q-cycle and is prerequisite to vectorial proton translocation. The widely accepted Q-cycle reaction scheme describes the overall electron and proton pathways, but does not address the detailed chemistry of this central step. Based on a model of the ubihydroquinone-oxidation pocket containing two ubiquinone molecules in a stacked configuration, a detailed model for the reactions during steady-state catalysis is proposed. In this proton-gated charge-transfer mechanism the reaction is controlled by the deprotonation of the substrate ubihydroquinone.
【 授权许可】
Unknown
【 预 览 】
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