Interleukin‐4 upregulates the heat shock protein Hsp90α and enhances transcription of a reporter gene coupled to a single heat shock element

FEBS Letters

Ezernieks, Juris¹  Sebald, Walter¹  Duschl, Albert¹  Metz, Kurt¹ 

[1]Theodor-Boveri-Institut fur Biowissenschaften (Biozentrum), Physiologische Chemie II, Am Hubland, D-97074 Würzburg, Germany

关键词: Hsp90α;    Heat shock factor;    Heat shock element;    Interleukin-4;    Interleukin-2;    Interleukin-13;    CAT;    chloramphenicol acetyltransferase;    GM-CSF;    granulocyte-macrophage colony-stimulating factor;    IL;    interleukin;    HSE;    heat shock element;    HSF;    heat shock factor;    Hsp;    heat shock protein;    PHA;    phytohemagglutinin;    TK;    thymidine kinase of herpes simplex virus;   

DOI  :  10.1016/0014-5793(96)00341-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcription of the heat shock protein Hsp90α was strongly upregulated in human T-cells by interleukin-4 (IL-4) and to a lesser extent by IL-2, reaching peak levels after 2–3 days of stimulation. Heat shock proteins are induced within minutes under stress conditions, via heat shock factors (HSF), which activate heat shock elements (HSE). IL-4, IL-2 and IL-13 upregulated transcription of a reporter gene coupled to a single HSE site and a minimal promoter. HSE may therefore be involved in cytokine induced heat shock gene transcription in the absence of cellular stress.

【 授权许可】

Unknown