Temporal regulation of gene expression in adipocyte differentiation

FEBS Letters

Chen, Suzie¹  Martino, Jeffrey J.¹ 

[1] Department of Chemical Biology, Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA

关键词: Adipocyte differentiation;    RNA expression;    Temporal regulation;   

DOI  :  10.1016/0014-5793(96)00254-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Cells usually become ‘committed’ to differentiate long before any actual morphological change is apparent. In one model commitment is a decision which corresponds to the expression of a control gene, while differentiation is the ultimate consequence of that decision. We have been studying adipocyte commitment and differentiation at the molecular level. Earlier we showed that the introduction of a specific DNA sequence into ‘uncommitted’ cells renders those cells committed to differentiate into adipocytes. Here we report temporal regulation of the expression of this DNA sequence; furthermore, we show that this RNA is in the non-polyA⁺ fraction of total cellular RNA. These data suggest that coordinate regulation of this and other genes is important in promoting differentiation.

【 授权许可】

Unknown