Is there an unidentified defence mechanism against infection in human plasma?

FEBS Letters

Aejmelaeus, R.³  Metsä-Ketelä, T.³  Alho, H.¹  Laippala, P.² 

[1]Laboratory of Neurobiology, Medical School, University of Tampere, P.O. Box 607, 33101 Tampere, Finland

[2]Department of Biometrics, School of Public Health, University of Tampere, P.O. Box 607, 33101 Tampere, Finland

[3]Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical School, University of Tampere, P.O. Box 607, 33101 Tampere, Finland

关键词: Antioxidants;    Unidentified antioxidants;    Infection;    Ascorbic acid;    TRAP;    total peroxyl radical scavenging capacity;    AA;    ascorbic acid;    PMN;    polymorphonuclear neutrophil;    CRP;    C-reactive protein;    ESR;    sedimentation rate;    ABAP;    2;    2′-azobis [2-amidinopropane] hydrochloride;    SH-groups;    sulphhydryl-groups;    CL;    chemiluminescence;    UNID;    unidentified antioxidants;   

DOI  :  10.1016/0014-5793(96)00296-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The total peroxyl radical scavenging capacity (TRAP) of human plasma was measured from pneumonia patients and controls. TRAP and its main components, ascorbic acid, alpha-tocopherol, uric acid or protein thiol groups, were unaltered, but the concentration of unidentified antioxidants in pneumonia patients was significantly reduced. Our results indicate that human plasma may contain so far unidentified antioxidants depleted in infection.

【 授权许可】

Unknown