Identification of alternative splicing form of Stat2

FEBS Letters

Nishio, Yukihiro¹  Kishimoto, Tadamitsu¹  Sugiyama, Tetsuya¹  Akira, Shizuo¹ 

[1] Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-oka, Suita, Osaka 565, Japan

关键词: Stat2;    IFN-α/β signaling;    Alternative splicing;    SH2 domain;    IFN;    interferon;    Stat;    signal transducers and activators of transcription;    Jak;    Janus kinase;    ISGF3;    IFN-stimulated gene factor 3;   

DOI  :  10.1016/0014-5793(96)00121-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We identified alternatively spliced forms of Stat2 in human and mouse mRNAs. The spliced forms are generated by reading through the intron between exon 20 and 21, which correspond to the region encoding SH2 domain. The spliced forms contain a stop codon in SH2 domain, and therefore give rise to a short form of Stat2 when the mRNAs are translated. The putative translated proteins lack half of the SH2 domain, the tyrosine phosphorylation site required for dimerization (or oligomereization) and DNA binding, and C-terminal activation domain. The significance of these spliced forms is discussed.

【 授权许可】

Unknown