Interferons induce accumulation of diadenosine triphosphate (Ap3A) in human cultured cells

FEBS Letters

Kisselev, L.¹  Vartanian, A.¹  Amchenkova, A.²  Turpaev, K.¹  Narovlyansky, A.² 

[1] Engelhardt Institute of Molecular Biology, Russian Academy Sciences, 32 Vavilov Street, 117984 Moscow B-334, Russia;Gamaleya Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russia

关键词: Interferon;    Truptophanyl-tRNA synthetase;    Ap3A synthesis;    Human cultured cell;   

DOI  :  10.1016/0014-5793(96)00073-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

After incubation of human monocytes J96 and human myeloid leukemia HL60 cells with interferons (IFN) α or γ, the Ap₃A concentration considerably increases in parallel with accumulation of tryptophanyl-tRNA synthetase (TrpRS, EC 6.1.1.2) The Ap₃A formation in response to IFNs is catalysed by an excessive amount of TrpRS. Although the Ap₃A function still remain unknown its accumulation may imply the Ap₃A involment in the IFN-signalling pathway.

【 授权许可】

Unknown