Protection against peroxynitrite‐dependent tyrosine nitration and α 1‐antiproteinase inactivation by oxidized and reduced lipoic acid

FEBS Letters

Halliwell, Barry²  Whiteman, Matthew²  Tritschler, Hans¹ 

[1] Asta Medica, Weismullerstrasse 45, 6000 Frankfurt am Main, Germany;Neurodegenerative Disease Research Centre, King's College, Manresa Road, London SW3 6LX, UK

关键词: Lipoic acid;    Peroxynitrite;    Nitrotyrosine;    α 1-Antiproteinase;    Nitric oxide;    Superoxide;   

DOI  :  10.1016/0014-5793(95)01489-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Peroxynitrite, formed by combination of superoxide radical with nitric oxide, is a reactive tissue-damaging species apparently involved in the pathology of several human diseases. Peroxynitrite nitrates tyrosine residues and inactivates α ₁-antiprotinase. We show that both lipoic acid and dihydrolipoic acid efficiently protect against damage by peroxynitrite. By contrast, other disulphides tested did not. The biological antioxidant effects of lipoate/dihydrolipoate may involve scavenging of reactive nitrogen species as well as reactive oxygen species.

【 授权许可】

Unknown