Activin A‐induced apoptosis is suppressed by BCL‐2

FEBS Letters

Krajewski, Stanislaw²  Koseki, Takeyoshi³  Tsujimoto, Yoshihide¹  Nishihara, Tatsuji³  Yamato, Kenji³  Reed, John C.² 

[1] Biomedical Research Center, Osaka University Medical School, 2-2, Yamadaoka, Suita, Osaka, 565, Japan;La Jolla Cancer Research Foundation, Cancer Research Center, 10901 North Torrey Pines Road, 419 North Building, La Jolla, CA 92037, USA;Department of Oral Science, The National Institute of Health, 1-23-1 Toyama, Shinjuku-ku, Tokyo 162, Japan

关键词: Activin A;    Apoptosis;    BAX;    BCL-2;    Programmed cell death;   

DOI  :  10.1016/0014-5793(95)01290-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Activin A, a member of TGFβ superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL-2 and BAX, and the effect of BCL-2 overexpression on activin A-induced apoptosis in B cell hybridoma cell lines. The activin A-sensitive cell lines expressed BAX but not BCL-2 and that activin A did not increase BAX levels. Overexpression of human BCL-2 suppressed activin A-induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL-2-inhibitable mechanism without activating BAX.

【 授权许可】

Unknown