Characterisation of a synergohymenotropic toxin produced by Staphylococcus intermedius

FEBS Letters

Monteil, H.¹  Bouakham, T.¹  Prevost, G.¹  Piemont, Y.¹ 

[1] Institut de Bactériologie de la Faculté de Médecine de Strasbourg, 3 rue Koeberlé, F-67000 Strasbourg, France

关键词: Synergohymenotropic toxin;    Staphylococcus intermedius;    LukS-I;    LukF-I;    Leukotoxicity;    Dermonecrosis;    Virulence factor;   

DOI  :  10.1016/0014-5793(95)01260-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Staphylococcal synergohymenotropic (SHT) toxins damage membranes of host defence cells and erythrocytes by the synergy of two secreted and non-associated proteins: class S and class F components. Whereas Panton-Valentine leucocidin (PVL), γ-hemolysin and Luk-M from Staphylococcus aureus are members of this toxin family, a new bi-component toxin (LukS-I + LukF-I) from Staphylococcus intermedius, a pathogen for small animals, was characterised and sequenced. It is encoded as a luk-I operon by two cotranscribed genes, like PVL. LukS-I + LukF-I shares a strong leukotoxicity of various PMNs, but only slight haemolytic properties on rabbit erythrocytes. When intradermally injected into rabbit skin, a 100 ng dose caused acute inflammatory reaction leading to tissue necrosis. The new SHT seemed to be largely distributed among various Staphylococcus intermedius strains.

【 授权许可】

Unknown